High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring

  title={High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring},
  author={Huberdina P. M. Smedts and J H M de Vries and Maryam Rakhshandehroo and M. F. Wildhagen and Anna C. Verkleij-Hagoort and Eric A. P. Steegers and R.P.M. Steegers-Theunissen},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
Objective  To study associations between maternal dietary and supplement intake of antioxidants vitamin E, retinol and congenital heart defects (CHDs). 
The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women
Please cite this paper as: Alwan N, Greenwood D, Simpson N, McArdle H, Cade J. The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women.
Maternal intake of vitamin E and birth defects, national birth defects prevention study, 1997 to 2005.
BACKGROUND In a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs). To explore this association further, we
Maternal Dietary Patterns during Pregnancy and Congenital Heart Defects: A Case-Control Study
Maternal diet during pregnancy is an important target for intervention, and it may influence the likelihood of developing CHDs, especially in women with high scores on the dairy and egg pattern.
The effect of maternal iron status and intake during pregnancy on cardiovascular disease risk in the offspring
Maternal iron intake and status in early pregnancy seem to be associated with short term birth outcomes like size at birth, while associations with long term offspring cardiovascular indicators were not detected in this thesis.
Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients
It is suggested that increasing prenatal vitamin supplementation to the levels recommended here may reduce the incidence of many pregnancy complications and infant health problems which currently occur.
Association of maternal dietary habits and ADIPOQ gene polymorphisms with the risk of congenital heart defects in offspring: a hospital-based case-control study
Maternal dietary habits, ADIPOQ gene, and their interactions show a significant association with the risk of CHDs, however, the findings need to be taken with caution, which highlights that more studies are required to further corroborate the findings.
Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure
Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age.


Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease
Objective  To investigate the inter‐relation between mother and infant homocysteine, folate and vitamin B12 status and the risk of a child with congenital heart disease (CHD).
Dietary intake of B-vitamins in mothers born a child with a congenital heart defect
A diet low in vitamin B12 is associated with an increased risk of a child with a CHD, especially in low educated women, and may imply that the hyperhomocysteinemic mothers and their children should be targeted for nutritional interventions.
Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps
The evidence is reviewed and the evidence suggested is a framework for further investigation in this area, and the use of multivitamin supplements around the time of conception and during early pregnancy with a reduced risk for heart defects in the offspring is suggested.
Maternal Western Dietary Patterns and the Risk of Developing a Cleft Lip With or Without a Cleft Palate
The use of the maternal Western diet increases the risk of offspring with a cleft lip or cleft palate approximately two fold, and dietary and lifestyle profiles should be included in preconception screening programs.
Vitamin A and Cardiac Outflow Tract Defects
Assessment of the relationship between maternal intake of vitamin A and cardiac outflow tract defects among liveborn infants born from 1987 through 1989 to mothers residing in the Baltimore-Washington area found that similar intakes of carotenoids and dietary retinol were not associated with an increased risk for either type of outflows tract defect.
Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism.
A metabolic profile that is predictive of congenital heart defect risk would help to refine current nutritional intervention strategies to reduce risk and may provide mechanistic clues for further experimental studies.
Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads
The adapted FFQ is a reliable tool to estimate the dietary intake of energy, macronutrients, folate and vitamin B12 in women of reproductive age and is suitable for the investigation of nutrient-disease associations in future.
Congenital heart defects and maternal biomarkers of oxidative stress.
Biomarkers of oxidative stress involved in the transsulfuration pathway were significantly higher in women with pregnancies affected by congenital heart defects than in women without such a history.