High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring

@article{Smedts2009HighMV,
  title={High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring},
  author={H. P. Smedts and J. D. de Vries and M. Rakhshandehroo and M. Wildhagen and A. Verkleij-Hagoort and E. Steegers and R. Steegers-Theunissen},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2009},
  volume={116}
}
Objective  To study associations between maternal dietary and supplement intake of antioxidants vitamin E, retinol and congenital heart defects (CHDs). 
The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women
Please cite this paper as: Alwan N, Greenwood D, Simpson N, McArdle H, Cade J. The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women.Expand
Association of maternal dietary intakes and CBS gene polymorphisms with congenital heart disease in offspring.
TLDR
Maternal dietary factors, CBS genetic variants and their interactions were significantly associated with risk ofCHD in offspring, however, it is still unclear how these factors jointly work in the development of CHD, and more studies with larger samples and prospective design are required. Expand
Maternal intake of vitamin E and birth defects, national birth defects prevention study, 1997 to 2005.
BACKGROUND In a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs). To explore this association further, weExpand
A compromised maternal vitamin D status is associated with congenital heart defects in offspring.
TLDR
A compromised maternal vitamin D status is associated with an approximately two-fold increased prevalence of CHD in offspring, and improvement of the periconceptional maternal vitaminD status is recommended. Expand
Maternal Dietary Patterns during Pregnancy and Congenital Heart Defects: A Case-Control Study
TLDR
Maternal diet during pregnancy is an important target for intervention, and it may influence the likelihood of developing CHDs, especially in women with high scores on the dairy and egg pattern. Expand
The effect of maternal iron status and intake during pregnancy on cardiovascular disease risk in the offspring
TLDR
Maternal iron intake and status in early pregnancy seem to be associated with short term birth outcomes like size at birth, while associations with long term offspring cardiovascular indicators were not detected in this thesis. Expand
Association of maternal dietary habits and ADIPOQ gene polymorphisms with the risk of congenital heart defects in offspring: a hospital-based case-control study
TLDR
Maternal dietary habits, ADIPOQ gene, and their interactions show a significant association with the risk of CHDs, however, the findings need to be taken with caution, which highlights that more studies are required to further corroborate the findings. Expand
The Role of Vitamin E in Pregnancy
TLDR
Considerable scientific work remains necessary to fully understand the role of vitamin E in fertility and pregnancy and its ability to optimize maternal and neonatal outcomes. Expand
Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure
TLDR
Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age. Expand
Vitamins, Minerals, Trace Elements, and Dietary Supplements
TLDR
There is evidence for the apparent safety and potentially therapeutic benefit of vitamin B 6, folic acid, calcium, coenzyme Q10, chromium, and zinc, and there may be an increased risk of harm when vitamin A is administered above 6000 IU daily. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Congenital heart defects and maternal derangement of homocysteine metabolism.
TLDR
Maternal hyperhomocysteine concentrations were significantly higher in the study group as compared with 56 control subjects, suggesting that mother-child friendship may be a risk factor for congenital heart defects. Expand
Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease
Objective  To investigate the inter‐relation between mother and infant homocysteine, folate and vitamin B12 status and the risk of a child with congenital heart disease (CHD).
Dietary intake of B-vitamins in mothers born a child with a congenital heart defect
TLDR
A diet low in vitamin B12 is associated with an increased risk of a child with a CHD, especially in low educated women, and may imply that the hyperhomocysteinemic mothers and their children should be targeted for nutritional interventions. Expand
Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps
TLDR
The evidence is reviewed and the evidence suggested is a framework for further investigation in this area, and the use of multivitamin supplements around the time of conception and during early pregnancy with a reduced risk for heart defects in the offspring is suggested. Expand
Maternal Western Dietary Patterns and the Risk of Developing a Cleft Lip With or Without a Cleft Palate
TLDR
The use of the maternal Western diet increases the risk of offspring with a cleft lip or cleft palate approximately two fold, and dietary and lifestyle profiles should be included in preconception screening programs. Expand
Vitamin A and Cardiac Outflow Tract Defects
TLDR
Assessment of the relationship between maternal intake of vitamin A and cardiac outflow tract defects among liveborn infants born from 1987 through 1989 to mothers residing in the Baltimore-Washington area found that similar intakes of carotenoids and dietary retinol were not associated with an increased risk for either type of outflows tract defect. Expand
Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism.
TLDR
A metabolic profile that is predictive of congenital heart defect risk would help to refine current nutritional intervention strategies to reduce risk and may provide mechanistic clues for further experimental studies. Expand
Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial
TLDR
Concomitant supplementation with vitamin C and vitamin E does not prevent pre-eclampsia in women at risk, but does increase the rate of babies born with a low birthweight, and use of these high-dose antioxidants is not justified in pregnancy. Expand
Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads
TLDR
The adapted FFQ is a reliable tool to estimate the dietary intake of energy, macronutrients, folate and vitamin B12 in women of reproductive age and is suitable for the investigation of nutrient-disease associations in future. Expand
Congenital heart defects and maternal biomarkers of oxidative stress.
TLDR
Biomarkers of oxidative stress involved in the transsulfuration pathway were significantly higher in women with pregnancies affected by congenital heart defects than in women without such a history. Expand
...
1
2
3
4
5
...