High mast cell density indicates a longer overall survival in oral squamous cell carcinoma

Abstract

This study evaluates the effects of tumour-associated mast cells on the prognosis of patients suffering from oral squamous cell carcinoma (OSCC). Tryptase-positive (MCT+) and CD117-positive (CD117+) mast cells were immunohistochemically evaluated in tissue samples of 118 OSCC patients. Besides, various clinicopathological parameters, the influence of the MCT+ and CD117+ mast cell density on overall survival and the incidence of first local recurrence was analysed by Cox regression and competing risk regression. Among all investigated parameters, multiple Cox regression revealed a significant influence of the MCT+ (cut-off at 14.87 mast cells/mm2 stroma; p = 0.0027) and CD117+ mast cell density (cut-off at 33.19 mast cells/mm2 stroma; p = 0.004), the age at primary diagnosis, and the T and N stage (all p-values < 0.05) on overall survival. Patients with a low mast cell density showed a significantly poorer overall survival rate compared to those with a high mast cell density in the tumour-associated stroma. Competing risk regression revealed a significant influence of the resection status (R) on the incidence of first local recurrence (p = 0.0023). A high mast cell density in the tumour-associated stroma of oral squamous cell carcinoma indicates a longer patient survival.

DOI: 10.1038/s41598-017-15406-5

Cite this paper

@inproceedings{Brockmeyer2017HighMC, title={High mast cell density indicates a longer overall survival in oral squamous cell carcinoma}, author={Phillipp Brockmeyer and Alexander Kling and Xenia Schulz and Christina Perske and Henning Schliephake and Bernhard Hemmerlein}, booktitle={Scientific reports}, year={2017} }