High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection.

@article{Lavine2012HighmannoseGE,
  title={High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection.},
  author={C. Lavine and Socheata Lao and David C. Montefiori and Barton F. Haynes and Joseph Sodroski and Xinzhen Yang},
  journal={Journal of virology},
  year={2012},
  volume={86 4},
  pages={2153-64}
}
Broad and potent neutralizing antibody (BNAb) responses are rare in people infected by human immunodeficiency virus type 1 (HIV-1). Clearly defining the nature of BNAb epitopes on HIV-1 envelope glycoproteins (Envs) targeted in vivo is critical for future directions of anti-HIV-1 vaccine development. Conventional techniques are successful in defining neutralizing epitopes in a small number of individual subjects but fail in studying large groups of subjects. Two independent methods were… CONTINUE READING
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