High male chimerism in the female breast shows quantitative links with cancer

@article{Dhimolea2013HighMC,
  title={High male chimerism in the female breast shows quantitative links with cancer},
  author={Eugen Dhimolea and Vikt{\'o}ria D{\'e}nes and Monika Lakk and Sana Al-Bazzaz and Sonya Aziz-Zaman and Monika E Pilichowska and Peter Geck},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
Clinical observations suggest that pregnancy provides protection against cancer. The mechanisms involved, however, remain unclear. Fetal cells are known to enter the mother's circulation during pregnancy and establish microchimerism. We investigated if pregnancy‐related embryonic/fetal stem cell integration plays a role in breast cancer. A high‐sensitivity Y‐chromosome assay was developed to trace male allogeneic cells (from male fetus) in females. Fixed‐embedded samples (n = 206) from both… 
Heterogeneous Distribution of Fetal Microchimerism in Local Breast Cancer Environment
TLDR
A heterogeneous distribution of fetal microchimerism in breast cancer environment is found and in women with sons, breast neoplasia harbors male cells at significantly higher levels than in peripheral and normal breast tissue.
Male origin microchimerism and ovarian cancer.
TLDR
It is reported for the first time that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who Test negative.
Novel insights into the link between fetal cell microchimerism and maternal cancers
TLDR
Biological mechanisms by which fetal cell microchimerism is believed to modulate the protection against cancer development or tumor progression will be discussed, together with findings in animal models.
Fetal cell microchimerism in papillary thyroid cancer: A role in the outcome of the disease
Fetal cell microchimerism (FCM) is defined as the persistence of fetal cells in maternal organs and circulation without any apparent rejection and it was hypothesized to protect toward the onset of
Effects of Fetal Microchimerism on Female Breast Cancer: State of the Art and Evolutionary Point of View
  • D. N, Gueye M.V., F. O
  • Medicine, Biology
    African Journal of Biology and Medical Research
  • 2022
TLDR
This study found microchimerism more in healthy women than women with breast cancer, with a statistically significant difference, and indicates that microchemical cells may help reduce the risk of breast cancer in women.
Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health
  • J. Bryan
  • Biology, Medicine
    The AAPS Journal
  • 2015
TLDR
The current state of understanding of fetal microchimerism in humans and dogs is described and the similarities of the common cancers mammary carcinoma, lymphoma, and colon cancer between the two species are highlighted.
Symptotic detection of chimerism
TLDR
To study chimerism in breast cancer this work took advantage of the evolutionary history of the Y chromosome and designed amplicons on gene repeats to generate additive PCR signals and increased sensitivity detected high incidence of male chimerist in normal breast tissues.
The health effects of fetal microchimerism can be modeled in companion dogs
TLDR
Golden Retrievers suggest that male cells carried by the dam from previous pregnancy trafficked to her daughters to establish microchimerism in younger siblings, which suggests that mechanisms useful for clinical interventions in humans are elucidated.
The occurrence of fetal microchimeric cells in endometrial tissues is a very common phenomenon in benign uterine disorders, and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses.
TLDR
A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade, and stage of the tumor.
Impact of Male Origin Microchimerism on Cardiovascular Disease in Women: A Prospective Cohort Study.
TLDR
The findings show that microchimerism-positivity is associated with a lower rate of later IHD development in women, and may be relevant in women's cardiovascular health.
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