High lung inflation increases mRNA levels of ECM components and growth factors in lung parenchyma.

Abstract

Remodeling of pulmonary capillaries occurs after chronic increases in capillary pressure (e.g., mitral stenosis). Also, remodeling of pulmonary arteries begins within 4 h of increased wall stress and is endothelium dependent. We have previously shown that high lung inflation increases wall stress in pulmonary capillaries. This study was designed to… (More)

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@article{Berg1997HighLI, title={High lung inflation increases mRNA levels of ECM components and growth factors in lung parenchyma.}, author={J. E. T. van den Berg and Z. Fu and Elizabeth Crabb Breen and Hung Tran and Odile Mathieu-Costello and J. B. West}, journal={Journal of applied physiology}, year={1997}, volume={83 1}, pages={120-8} }