High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator.

@article{Sopasakis2004HighLC,
  title={High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator.},
  author={Victoria Rotter Sopasakis and Madel{\'e}ne Sandqvist and Birgit Gustafson and Ann Hammarstedt and Martin Schmelz and Xiaolin Yang and Per-Anders Jansson and Ulf Smith},
  journal={Obesity research},
  year={2004},
  volume={12 3},
  pages={454-60}
}
OBJECTIVE To examine the possibility that interleukin-6 (IL-6) can act as a paracrine regulator in adipose tissue by examining effects on adipogenic genes and measuring interstitial IL-6 concentrations in situ. RESEARCH METHODS AND PROCEDURES Circulating and interstitial IL-6 concentrations in abdominal and femoral adipose tissue were measured using the calibrated microdialysis technique in 20 healthy male subjects. The effects of adipose cell enlargement on gene expression and IL-6 secretion… CONTINUE READING
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