High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.

@article{Liu2005HighLL,
  title={High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.},
  author={Enqi Liu and Shuji Kitajima and Yasuki Higaki and Masatoshi Morimoto and Huijun Sun and Teruo Watanabe and Nobuhiro Yamada and Jianglin Fan},
  journal={Metabolism: clinical and experimental},
  year={2005},
  volume={54 1},
  pages={132-8}
}
Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of triglyceride-rich lipoproteins and plays an important role in glucose metabolism. To examine the hypothesis that increased LPL activity may alter insulin sensitivity, we investigated glucose metabolism and insulin sensitivity in transgenic (Tg) rabbits expressing the human LPL gene under the control of a I(2) -actin promoter. An intravenous glucose tolerance test showed that the plasma glucose clearance rate was not… CONTINUE READING