High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.

@article{Eriksson2009HighLO,
  title={High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.},
  author={Sofi E. Eriksson and Stefanie Prast-Nielsen and Emilie Flaberg and L{\'a}szl{\'o} Sz{\'e}kely and Elias S J Arn{\'e}r},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 11},
  pages={1661-71}
}
The selenoprotein thioredoxin reductase 1 (TrxR1) is currently recognized as a plausible anticancer drug target. Here we analyzed the effects of TrxR1 targeting in the human A549 lung carcinoma cell line, having a very high basal TrxR1 expression. We determined the total cellular TrxR activity to be 271.4 +/- 39.5 nmol min(-1) per milligram of total protein, which by far exceeded the total thioredoxin activity (39.2 +/- 3.5 nmol min(-1) per milligram of total protein). Knocking down TrxR1 by… CONTINUE READING
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