High levels of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain.

@article{Saporito1995HighLO,
  title={High levels of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain.},
  author={Michael S. Saporito and Sean Carswell},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 3 Pt 2},
  pages={2280-6}
}
NGF found in the basal forebrain is believed to be localized to NGF-dependent cholinergic neurons and derived via retrograde axonal transport from NGF-synthesizing target hippocampal and cortical neurons. The basis for this concept of target-derived NGF is the detection of only limited amounts of NGF mRNA in the basal forebrain, despite relatively high NGF levels there. Our work, using a more sensitive and quantitative RNase protection method for detecting relative NGF mRNA levels, suggested… CONTINUE READING

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