High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

@article{Bender2006HighLO,
  title={High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease},
  author={A. Bender and K. J. Krishnan and C. Morris and G. Taylor and A. Reeve and R. Perry and E. Jaros and J. Hersheson and J. Betts and T. Klopstock and Robert W Taylor and D. Turnbull},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={515-517}
}
Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA) (controls, 43.3% ± 9.3%; individuals with Parkinson disease, 52.3% ± 9.3%). These mtDNA mutations are somatic, with different clonally expanded deletions in individual cells, and high levels of these mutations are associated with respiratory chain deficiency. Our studies suggest that somatic mtDNA deletions are important in the… Expand

Paper Mentions

Nature of mitochondrial DNA deletions in substantia nigra neurons.
The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration
Detrimental deletions: mitochondria, aging and Parkinson's disease.
  • S. Biskup, D. Moore
  • Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2006
Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions
Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism
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