High levels of interferon alpha in the sera of children with dengue virus infection.

@article{Kurane1993HighLO,
  title={High levels of interferon alpha in the sera of children with dengue virus infection.},
  author={Ichiro Kurane and Bruce L. Innis and Suchitra Nimmannitya and Ananda N Nisalak and Anthony Meager and Francis A. Ennis},
  journal={The American journal of tropical medicine and hygiene},
  year={1993},
  volume={48 2},
  pages={222-9}
}
We measured the levels of interferon alpha (IFN alpha) in the sera of Thai children hospitalized with dengue hemorrhagic fever (DHF) or dengue fever (DF) to examine the role of IFN alpha in dengue virus infections of humans. The percentage of patients who had detectable levels of IFN alpha (> or = 3 U/ml) was higher in patients with DHF (80%, P < 0.001) and in patients with DF (60%, P < 0.001) than in healthy Thai children (7%). The levels of IFN alpha were higher in patients with DHF and in… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 17 references

Activation ofT lymphocytesin denguevirus infections.High levels of soluble interleukin-2 receptor, soluble CD4, soluble CD8, interleukin 2 and interfer on-'y in sera of children with dengue

  • I Kurane, BL Innis, A Nimmannitya S. Nisalak, MeagerA, J Janus, FA Ennis
  • J Clin Invest 88:1473—1480
  • 1991

Denguevirus-specificcross reactive CD8@ human cytotoxic T lymphocytes

  • JF Bukowski, I Kurane, C-J Lai, M Bray, B Galbout, PA Ennis
  • J Virol63:2486—2491
  • 1989

1987.Monoclonalantibodies against den gue 2 virus E-glycoprotein protect mice against lethal dengue infection

  • BM Kaufman, PL Summer, DR Dubois, KH Eckeis
  • Am J Trop Med Hyg
  • 1987

Monoclonalantibodiesagainstden gue 2 virus Eglycoprotein protect mice against lethal dengue infection

  • BM Kaufman, PL Summer, DR Dubois, KH Eckeis
  • Am J Trop Med Hyg
  • 1987

De veiopment of interferonspecific monocional an tibody for in vitro interferon assays

  • A Meager, K Berg
  • Dev Biol Standard
  • 1986

Epitope iocalization of a monocional antibody , LO22 , with broad specificity for interferonsubtypes

  • T Exicy, 5 Parti, 5 Barwick, A Meager
  • J Interferon Res
  • 1986

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