High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes.


The regenerating liver after partial hepatectomy is one of the few physiologic models of cellular proliferation in the adult animal. During hepatic regeneration, the animal is able to maintain metabolic homeostasis despite the acute loss of two thirds of hepatic tissue. In examining the molecular mechanisms regulating hepatic regeneration, we isolated novel… (More)


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