High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.

Abstract

The prognostic impact of global DNA methylation and hydroxymethylation was assessed in 90 patients with de novo myelodysplastic syndrome (MDS). DNA was isolated from bone marrow samples obtained at diagnosis and global methylation and hydroxymethylation were determined by ELISA. Patients with a percentage of methylated DNA above 2.73% had a shorter overall… (More)
DOI: 10.1016/j.leukres.2014.04.015

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@article{Calvo2014HighLO, title={High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.}, author={Xavier Calvo and Meritxell Nomdedeu and Alfons Navarro and Rut Tejero and Dolors Costa and Concha Mu{\~n}oz and A. Lopes Pereira and Oscar Pe{\~n}a and Ruth M Risue{\~n}o and Mariano Monz{\'o} and Jordi Esteve and Benet Nomdedeu}, journal={Leukemia research}, year={2014}, volume={38 8}, pages={874-81} }