High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.

@article{Calvo2014HighLO,
  title={High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.},
  author={Xavier Calvo and Meritxell Nomdedeu and Alfons Navarro and Rut Tejero and Dolors Costa and C. Ivonne Mu{\~n}oz and Arturo Pereira and Oscar Pe{\~n}a and Ruth M Risue{\~n}o and M Monzo and Jordi Esteve and Benet Nomdedeu},
  journal={Leukemia research},
  year={2014},
  volume={38 8},
  pages={874-81}
}
The prognostic impact of global DNA methylation and hydroxymethylation was assessed in 90 patients with de novo myelodysplastic syndrome (MDS). DNA was isolated from bone marrow samples obtained at diagnosis and global methylation and hydroxymethylation were determined by ELISA. Patients with a percentage of methylated DNA above 2.73% had a shorter overall survival than those with lower levels (P=0.018) and presented a negative trend in terms of leukemia-free survival (P=0.084), that was… CONTINUE READING
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