High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix.

@article{Tierney2013HighLO,
  title={High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix.},
  author={Erica G Tierney and Kevin McSorley and Conn L. Hastings and Sally-Ann Cryan and Timothy O'Brien and Mary J. Murphy and F Barry and Fergal J O'Brien and Garry P. Duffy},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2013},
  volume={165 3},
  pages={173-82}
}
Gene therapy can be combined with tissue engineering constructs to produce gene-activated matrices (GAMs) with enhanced capacity for repair. Polyethyleneimine (PEI), a non-viral vector, has previously been optimised for high efficiency gene transfer in rat mesenchymal stem cells (rMSCs). The use of PEI to transfect human MSCs (hMSCs) with ephrinB2 is… CONTINUE READING