High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.

  title={High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.},
  author={Nora D. Volkow and Gene-Jack Wang and H. Begleiter and Bernice Porjesz and Joanna S. Fowler and Frank Telang and Christopher T Wong and Yeming Ma and Jean Logan and R. Goldstein and David A Alexoff and Peter K. Thanos},
  journal={Archives of general psychiatry},
  volume={63 9},
CONTEXT Predisposition to alcoholism is likely an interaction between genetic and environmental factors that confer vulnerability and protection. Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption. OBJECTIVES To test whether high levels of D(2) receptors may be protective against alcoholism and whether this is mediated by their modulation of activity in orbitofrontal cortex and… CONTINUE READING
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