High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.

@article{Volkow2006HighLO,
  title={High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.},
  author={Nora D. Volkow and Gene-Jack Wang and H. Begleiter and Bernice Porjesz and Joanna S. Fowler and Frank Telang and Christopher T Wong and Yeming Ma and Jean Logan and R. Goldstein and David A Alexoff and Peter K. Thanos},
  journal={Archives of general psychiatry},
  year={2006},
  volume={63 9},
  pages={
          999-1008
        }
}
CONTEXT Predisposition to alcoholism is likely an interaction between genetic and environmental factors that confer vulnerability and protection. Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption. OBJECTIVES To test whether high levels of D(2) receptors may be protective against alcoholism and whether this is mediated by their modulation of activity in orbitofrontal cortex and… CONTINUE READING
Highly Cited
This paper has 116 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Striatocortical pathway dysfunction in addiction and obesity: differences and similarities.

Critical reviews in biochemistry and molecular biology • 2013
View 7 Excerpts
Highly Influenced

Addiction circuitry in the human brain.

Annual review of pharmacology and toxicology • 2012
View 14 Excerpts
Highly Influenced

Addiction science: Uncovering neurobiological complexity

Neuropharmacology • 2014
View 23 Excerpts
Highly Influenced

Molecular Neurobiology of Addiction Recovery

SpringerBriefs in Neuroscience • 2013
View 2 Excerpts
Highly Influenced

Pro v Con Reviews: Is Food Addictive?: Obesity and addiction: neurobiological overlaps

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2013
View 6 Excerpts
Highly Influenced

116 Citations

01020'87'94'02'10'18
Citations per Year
Semantic Scholar estimates that this publication has 116 citations based on the available data.

See our FAQ for additional information.