High levels of divergent HIV-1 quasispecies in patients with neurological opportunistic infections in China

  title={High levels of divergent HIV-1 quasispecies in patients with neurological opportunistic infections in China},
  author={Yulin Zhang and Feili Wei and Qi Liang and Wei Ding and Luxin Qiao and Feng-li Song and Lifeng Liu and Sufang Yang and Ronghua Jin and Jianhua Gu and Ning Li and Dexi Chen},
  journal={Journal of NeuroVirology},
Despite the fact that the survival of people infected with human immunodeficiency virus (HIV) has improved worldwide because of the increasingly powerful and highly active antiretroviral therapy, opportunistic infections (OIs) of the central nervous system (CNS) remain a serious burden. HIV-1 is capable of entering the CNS through infected peripheral monocytes, but its effect on OIs of CNS remains unclear. In this study, we investigated the characteristics of HIV-1 in acquired immunodeficiency… 

Pharmacokinetics and Pharmacodynamics of Antiretrovirals in the Central Nervous System

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The sequence analysis indicated the significant differences between CSF and plasma was only observed in the C4 region in HAND patients, and discordant patterns of genetic evolution occur between the tissue-specific HIV-1 quasispecies in the HAND and non-HAND patients.

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  • L. Ene
  • Biology, Medicine
    Infectious diseases
  • 2018
As HIV can be responsible for considerable brain damage directly or by facilitating other pathogens, more effort is needed to recognize and manage HIV-associated CNS disorders and to eventually target HIV eradication from the brain.



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HIV infection in the central nervous system (CNS) can progress to AIDS dementia complex (ADC). Currently, the HIV-1 env gene in the CNS of infected Chinese paid blood donors (PBDs) has not been well

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Cerebrospinal fluid levels of chemokines in HIV infected patients with and without opportunistic infection of the central nervous system

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HIV-associated opportunistic infections of the CNS

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Key recent advances are reviewed in understanding of the neuropathogenesis of HIV, focusing on basic and clinical studies that reveal viral and host features associated with viral neuroinvasion, persistence, and immunopathogenesis in the CNS as well as issues related to monitoring and treatment of HIV-associated CNS injury in the current era.

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