High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome.

@article{Mori1999HighLO,
  title={High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome.},
  author={Miki Mori and Alan L Rothman and Ichiro Kurane and Juan Manuel Montoya and Kurt B. Nolte and James E Norman and D C Waite and Frederick T. Koster and Francis A. Ennis},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 2},
  pages={295-302}
}
Hantavirus pulmonary syndrome (HPS) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. Hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. Immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [IL]-1alpha, IL-1beta, IL-6, and tumor necrosis factor [TNF]-alpha; lymphokines: interferon-gamma, IL-2, IL-4, and TNF-beta) in… CONTINUE READING
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