High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer

@article{Ili2010HighLO,
  title={High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer},
  author={Marius Ili{\'e} and Nathalie M Mazure and V{\'e}ronique Hofman and Reda El Ammadi and C{\'e}cile Ortholan and Christelle Bonnetaud and Katia Havet and Nicolas V{\'e}nissac and Baharia Mograbi and J{\'e}r{\^o}me Mouroux and Jacques Pouyss{\'e}gur and Paul Hofman},
  journal={British Journal of Cancer},
  year={2010},
  volume={102},
  pages={1627 - 1635}
}
Background:Carbonic anhydrase IX (CAIX) is an enzyme upregulated by hypoxia during tumour development and progression. This study was conducted to assess if the expression of CAIX in tumour tissue and/or plasma can be a prognostic factor in patients with non-small cell lung cancer (NSCLC).Methods:Tissue microarrays containing 555 NSCLC tissue samples were generated for quantification of CAIX expression. The plasma level of CAIX was determined by ELISA in 209 of these NSCLC patients and in 58… CONTINUE READING

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