High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.

@article{Piatak1993HighLO,
  title={High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.},
  author={M. Piatak and M. Saag and L. C. Yang and S. J. Clark and J. Kappes and K. Luk and B. Hahn and G. Shaw and J. Lifson},
  journal={Science},
  year={1993},
  volume={259 5102},
  pages={
          1749-54
        }
}
  • M. Piatak, M. Saag, +6 authors J. Lifson
  • Published 1993
  • Medicine, Biology
  • Science
  • Quantitative competitive polymerase chain reaction (QC-PCR) methods were used to quantify virion-associated human immunodeficiency virus type-1 (HIV-1) RNA in plasma from 66 patients with Centers for Disease Control stage I to IVC1 infection. HIV-1 RNA, ranging from 100 to nearly 22,000,000 copies per milliliter of plasma (corresponding to 50 to 11,000,000 virions per milliliter), was readily quantified in all subjects, was significantly associated with disease stage and CD4+ T cell counts, and… CONTINUE READING
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