High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.

@article{Piatak1993HighLO,
  title={High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.},
  author={Michael Piatak and Michael S. Saag and L. C. Yang and Stephen J. Clark and John C Kappes and Kin-chun Luk and Beatrice H. Hahn and George M. Shaw and Jeffrey D. Lifson},
  journal={Science},
  year={1993},
  volume={259 5102},
  pages={
          1749-54
        }
}
Quantitative competitive polymerase chain reaction (QC-PCR) methods were used to quantify virion-associated human immunodeficiency virus type-1 (HIV-1) RNA in plasma from 66 patients with Centers for Disease Control stage I to IVC1 infection. HIV-1 RNA, ranging from 100 to nearly 22,000,000 copies per milliliter of plasma (corresponding to 50 to 11,000,000 virions per milliliter), was readily quantified in all subjects, was significantly associated with disease stage and CD4+ T cell counts, and… Expand
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