High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux.

@article{Chuanchuen2003HighlevelTR,
  title={High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux.},
  author={Rungtip Chuanchuen and RoxAnn R Karkhoff-Schweizer and Herbert P. Schweizer},
  journal={American journal of infection control},
  year={2003},
  volume={31 2},
  pages={124-7}
}
BACKGROUND Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. METHODS Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed. RESULTS The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps. 

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