High-level production of arachidonic acid by fed-batch culture of Mortierella alpina using NH4OH as a nitrogen source and pH control

@article{Hwang2005HighlevelPO,
  title={High-level production of arachidonic acid by fed-batch culture of Mortierella alpina using NH4OH as a nitrogen source and pH control},
  author={B. Hwang and Jin-Wook Kim and Chang-Yeol Park and Chang-Seo Park and Yong-Sung Kim and Yeon-woo Ryu},
  journal={Biotechnology Letters},
  year={2005},
  volume={27},
  pages={731-735}
}
Mortierella alpina was grown in a fed-batch culture using a 12-l jar fermenter with an initial 8-l working volume containing 20 g glucose l−1 and 10 g corn-steep powder l−1. Glucose was intermittently fed to give 32 g l−1 at each time. The pH of culture was maintained using 14% (v/v) NH4OH, which also acted as a nitrogen source. A final cell density of 72.5 g l−1 was reached after 12.5 days with a content of arachidonic acid (ARA) at 18.8 g l−1. These values were 4 and 1.8 times higher than the… CONTINUE READING

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