High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates.

Abstract

The successful engraftment of genetically modified hematopoietic stem cells (HSCs) without toxic conditioning is a desired goal for HSC gene therapy. To this end, we have examined the combination of intrabone marrow transplantation (iBMT) and in vivo expansion by a selective amplifier gene (SAG) in a nonhuman primate model. The SAG is a chimeric gene… (More)

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@article{Ueda2004HighlevelIV, title={High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates.}, author={Kyoji Ueda and Yutaka Hanazono and Hiroaki Shibata and Naohide Ageyama and Yasuji Ueda and Satoko Ogata and Toshiaki Tabata and Takeyuki Nagashima and Masaaki Takatoku and Akihiko Kume and Susumu Ikehara and Masafumi Taniwaki and Keiji Terao and Mamoru Hasegawa and Keiya Ozawa}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2004}, volume={10 3}, pages={469-77} }