High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.

@article{Apti2008HighLF,
  title={High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.},
  author={{\'A}gota Ap{\'a}ti and Tam{\'a}s I. Orb{\'a}n and N{\'o}ra Varga and Andrea H. N{\'e}meth and Anita Schamberger and Vir{\'a}g Kr{\'i}zsik and Bogl{\'a}rka Erd{\'e}lyi-Belle and L{\'a}szl{\'o} Homolya and Gy{\"o}rgy V{\'a}rady and Rita Pad{\'a}nyi and Eva Kar{\'a}szi and Evelien W. M. Kemna and Katalin N{\'e}met and Bal{\'a}zs Sarkadi},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 12},
  pages={
          2700-9
        }
}
Expression of multidrug resistance ABC transporters has been suggested as a functional marker and chemoprotective element in early human progenitor cell types. In this study we examined the expression and function of the key multidrug-ABC transporters, ABCB1, ABCC1 and ABCG2 in two human embryonic stem (HuES) cell lines. We detected a high level ABCG2 expression in the undifferentiated HuES cells, while the expression of this protein significantly decreased during early cell differentiation… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 46 CITATIONS

Workflow : Annotated pdf , CrossRef and tracked changes PROOF COVER SHEET

Gyoergy, Várady, +3 authors Sarkadi
  • 2015
VIEW 11 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Mesenchymal stem cell like (MSCl) cells generated from human embryonic stem cells support pluripotent cell growth.

  • Biochemical and biophysical research communications
  • 2011
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS

Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells.

  • Journal of stem cell research & therapy
  • 2014
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2.

  • Molecular cancer therapeutics
  • 2009
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

ABCG2 as a therapeutic target candidate for gout.

  • Expert opinion on therapeutic targets
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND