High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.

@article{Apti2008HighLF,
  title={High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.},
  author={{\'A}. Ap{\'a}ti and T. Orb{\'a}n and N. Varga and A. N{\'e}meth and Anita Schamberger and V. Kr{\'i}zsik and Bogl{\'a}rka Erd{\'e}lyi-Belle and L. Homolya and G. V{\'a}rady and Rita Pad{\'a}nyi and E. Kar{\'a}szi and E. Kemna and K. Német and B. Sarkadi},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 12},
  pages={
          2700-9
        }
}
  • Á. Apáti, T. Orbán, +11 authors B. Sarkadi
  • Published 2008
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Expression of multidrug resistance ABC transporters has been suggested as a functional marker and chemoprotective element in early human progenitor cell types. In this study we examined the expression and function of the key multidrug-ABC transporters, ABCB1, ABCC1 and ABCG2 in two human embryonic stem (HuES) cell lines. We detected a high level ABCG2 expression in the undifferentiated HuES cells, while the expression of this protein significantly decreased during early cell differentiation… CONTINUE READING
    79 Citations
    Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response
    • 21
    Gene and functional up-regulation of the BCRP/ABCG2 transporter in hepatocellular carcinoma
    • 37
    Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters.
    • 17
    ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy.
    • 253
    Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells.
    • 5
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 32 REFERENCES
    The ATP-binding Cassette Transporter ABCG2 (BCRP), a Marker for Side Population Stem Cells, Is Expressed in Human Heart
    • 93
    Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter.
    • 117