High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.

@article{Apti2008HighLF,
  title={High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.},
  author={{\'A}gota Ap{\'a}ti and Tam{\'a}s Istv{\'a}n Orb{\'a}n and N{\'o}ra Varga and Andrea H. N{\'e}meth and Anita Schamberger and Vir{\'a}g Kr{\'i}zsik and Bogl{\'a}rka Erd{\'e}lyi-Belle and L{\'a}szl{\'o} Homolya and Gy{\"o}rgy V{\'a}rady and Rita Pad{\'a}nyi and {\'E}va Kar{\'a}szi and Evelien Willemijn Maria Kemna and Katalin N{\'e}met and Bal{\'a}zs Sarkadi},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 12},
  pages={
          2700-9
        }
}
Expression of multidrug resistance ABC transporters has been suggested as a functional marker and chemoprotective element in early human progenitor cell types. In this study we examined the expression and function of the key multidrug-ABC transporters, ABCB1, ABCC1 and ABCG2 in two human embryonic stem (HuES) cell lines. We detected a high level ABCG2 expression in the undifferentiated HuES cells, while the expression of this protein significantly decreased during early cell differentiation… CONTINUE READING
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