High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice.

@article{Ashraf2005HighLE,
  title={High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice.},
  author={Shadma Ashraf and Pradhyumna Kumar Singh and Dinesh Kumar Yadav and Md Shahnawaz and Satish Mishra and Samir V Sawant and Rakesh Tuli},
  journal={Journal of biotechnology},
  year={2005},
  volume={119 1},
  pages={1-14}
}
A synthetic gene coding for the surface glycoprotein (G protein) of rabies virus was strategically designed to achieve high-level expression in transgenic plants. The native signal peptide was replaced by that of the pathogenesis related protein, PR-S of Nicotiana tabacum. An endoplasmic reticulum retention signal was included at C-terminus of the G protein. Tobacco plants were genetically engineered by nuclear transformation. Selected transgenic lines expressed the chimeric G protein at 0.38… CONTINUE READING

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