High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms☆

@inproceedings{Li2014HighLE,
  title={High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms☆},
  author={Ben-wen Li and Amy C. Rush and Gary J Weil},
  booktitle={International journal for parasitology. Drugs and drug resistance},
  year={2014}
}
Glutamate-gated chloride channels (GluCl) are targets for avermectin/milbemycin (A/M) anthelmintics such as ivermectin that cause paralysis of somatic and pharyngeal muscles in gastrointestinal nematodes. Ivermectin is useful for onchocerciasis control programs because of its activity against microfilariae that often cause ocular disease and severe dermatitis. However, mechanisms responsible for reduced microfilaria production by adult worms following ivermectin treatment are poorly understood… CONTINUE READING
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International journal for parasitology. Drugs and drug resistance • 2015
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References

Publications referenced by this paper.
Showing 1-10 of 59 references

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 5 Excerpts
Highly Influenced

The genetics of ivermectin resistance in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 6 Excerpts
Highly Influenced

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