High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia

@article{Skrby2006HighLD,
  title={High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia},
  author={T V Ch Sk{\"a}rby and Harald Anderson and Jesper Heldrup and Jukka A Kanerva and Holger Seidel and Kjeld Schmiegelow},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={1955-1962}
}
We explored the relationship between time to relapse and different exposure variables (serum methotrexate (S-MTX) 23, 36 and 42 h after start of administration, MTX elimination time and leucovorin (LV) dose) during high-dose MTX (HDM) treatment of 445 children with acute lymphoblastic leukemia. MTX was infused at 5 g/m2 (non-high risk) or 8 g/m2 (high risk) over 24 h, 2–9 times per patient. LV rescue dose was adjusted according to the S-MTX concentration. Time from end of the last HDM to… CONTINUE READING

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Ratio of methotrexate

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