High iodine concentration attenuates RET/PTC3 oncogene activation in thyroid follicular cells.

@article{Fiore2009HighIC,
  title={High iodine concentration attenuates RET/PTC3 oncogene activation in thyroid follicular cells.},
  author={Ana Paula Zen Petisco Fiore and Cesar Seigi Fuziwara and Edna T. Kimura},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2009},
  volume={19 11},
  pages={1249-56}
}
BACKGROUND Papillary thyroid carcinoma (PTC) is frequently associated with a RET gene rearrangement that generates a RET/PTC oncogene. RET/PTC is a fusion of the tyrosine kinase domain of RET to the 5' portion of a different gene. This fusion results in a constitutively active MAPK pathway, which plays a key role in PTC development. The RET/PTC3 fusion is primarily associated with radiation-related PTC. Epidemiological studies show a lower incidence of PTC in radiation-exposed regions that are… CONTINUE READING

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