High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension.

@article{Brown2017HighintensityIT,
  title={High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension.},
  author={Mary Beth Brown and Evandro M. N. Neves and Gary M. Long and Jeremy Graber and Brett Gladish and Andrew Wiseman and Matthew Owens and Amanda Jo Fisher and Robert G. Presson and Irina Petrache and Jeffrey A. Kline and Timothy Lahm},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2017},
  volume={312 2},
  pages={
          R197-R210
        }
}
Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute… CONTINUE READING
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