High intake of folic acid disrupts embryonic development in mice.

  title={High intake of folic acid disrupts embryonic development in mice.},
  author={Laura Pickell and Katharine V Brown and Deqiang Li and Xiaoling Wang and Liyuan Deng and Qing Wu and Jacob S Selhub and Li Luo and Loydie A Jerome-Majewska and Rima Rozen},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  volume={91 1},
BACKGROUND Folic acid fortification and supplementation has increased folate intake and blood folate concentrations and successfully reduced the incidence of neural tube defects. However, the developmental consequences of high folate intake are unknown. This study investigated the impact of high folate intake, alone or with methylenetetrahydrofolate reductase (MTHFR) deficiency, on embryonic and placental development in mice. METHODS Mthfr +/+ or +/- pregnant mice on a control diet (CD… CONTINUE READING
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