High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology.

@article{Hegde2005HighIO,
  title={High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology.},
  author={Upendra P. Hegde and Armando Carlos Filie and Richard F Little and John Janik and Nicole Drbohlav Grant and Seth Steinberg and Kieron Dunleavy and Elaine S. Jaffe and Andrea Abati and Maryalice Stetler-Stevenson and Wyndham H. Wilson},
  journal={Blood},
  year={2005},
  volume={105 2},
  pages={496-502}
}
We assessed the cerebrospinal fluid (CSF) by flow cytometry and cytology in 51 newly diagnosed and 9 treated aggressive B-cell lymphomas at risk for central nervous system (CNS) involvement to examine the utility of flow cytometry, incidence of CSF disease, and clinical surrogates of CNS spread. Multicolor flow cytometry using multiple antibody panels for light chains and B- and T-cell antigens identified neoplastic clones that constituted as little as 0.2% of total CSF lymphocytes. Among 51… CONTINUE READING