High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis

@article{Powell2001HighIO,
  title={High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis},
  author={Jennifer Powell and Andrew K. Robson and David W. Cranston and Fenella T. Wojnarowska and Robert A. Turner},
  journal={British Journal of Dermatology},
  year={2001},
  volume={145}
}
Background There is a well‐documented association between lichen sclerosus (LS) and vulval carcinoma in women; however, until recently, there have only been anecdotal reports of penile squamous cell carcinoma (SCC) occurring in men with LS.Objective The incidence of penile carcinoma occurring on a background of LS remains uncertain, and we wished to examine this possible association further.Method To address this, all the cases (n = 20) of penile SCC held on our pathology database (4 years… Expand
Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey.
TLDR
All patients with genital LS should be observed closely to detect the development of neoplastic or preneoplastic lesions as early as possible and survival of patients with penile carcinoma depends on early diagnosis and treatment. Expand
Malignant transformation of penile lichen sclerosus: exactly how common is it?
TLDR
It is suggested that in LS-associated penile CA, phimosis probably represents a more important carcinogenic factor than LS itself, and a possible solution to this apparent paradox is hypothesized. Expand
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TLDR
Seven out of 9 cases of penile cancer from this series were associated with this pattern, suggesting that it may correlate with a malignant degeneration, and the histological features observed in this last pattern may be interpreted as areas of disease reactivation within a chronic stage. Expand
Lichen sclerosus in boys.
  • K. Becker
  • Medicine
  • Deutsches Arzteblatt international
  • 2011
TLDR
LS is much more common in boys than is generally assumed and should be suspected in any case of acquired phimosis, and treatment with complete circumcision does not necessarily bring about a definitive cure. Expand
Lichen Sclerosus in 68 Patients With Squamous Cell Carcinoma of the Penis: Frequent Atypias and Correlation With Special Carcinoma Variants Suggests a Precancerous Role
TLDR
It is suggested that lichen sclerosus may represent preneoplastic condition for at least some types of penile cancers, in particular those not related to human papillomavirus. Expand
Squamous cell carcinoma of the penis: clinicopathologic study of 34 cases.
TLDR
The nonspecific clinical appearance of early lesions, insufficient medical training in skin lesions and lack of routine diagnostic investigation, treatment and follow up of these cases contribute to the poor prognosis of this neoplasm. Expand
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis
TLDR
The presence of histologically‐confirmed synchronous LS/BXO in patients diagnosed with pSCC is relatively high, although it is not associated with an increased risk of adverse histopathological features. Expand
Review of the male genital lichen sclerosus and urethral involvement
Lichen sclerosus (LS) previously known as balanitis xerotica obliterans, is a chronic, progressive lymphocyte mediated skin disease. It shows a predilection for the male genital area and may involveExpand
Microinvasive squamous cell carcinoma arising on lichen sclerosus of the penis
TLDR
The case of a 70‐year‐old white man with a 10‐year history of penile lichen sclerosus who developed microinvasive squamous cell carcinoma on LS is described and the authors stress the importance of an adequate diagnosis and long‐term follow‐up in patients with penile LS. Expand
Lichen sclerosus and squamous cell carcinoma.
TLDR
The relationship between lichen sclerosus and squamous cell and verrucous carcinomas, the possible oncogenic mechanisms involved, and their possible association with HPV infection are considered. Expand
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There was poor correlation between clinical and histological findings when SCC arose on a background of LS, and the incidence of SCC in vulval LS showed the incidence to be 7%. Expand
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Patients with genital LS are at considerable risk of the development of penile SCC, as well as other epithelial and in situ carcinomas, namely verrucous carcinoma and erythroplasia of Queyrat. Expand
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TLDR
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TLDR
Although direct evidence is lacking, these atypical lesions may serve to identify a population at increased risk for subsequent development of invasive carcinoma. Expand
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