High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy.

  title={High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy.},
  author={Marc Schindewolf and Corinna Gobst and Hartmut Kroll and Andreas Recke and Frank Louwen and Manfred Wolter and Roland Kaufmann and W. -H. Boehncke and Edelgard Lindhoff-Last and Ralf J Ludwig},
  journal={The Journal of allergy and clinical immunology},
  volume={132 1},
BACKGROUND Among the most frequent adverse effects of subcutaneous heparin treatment, heparin-induced skin lesions occur with an incidence of 10.3% in nonpregnant female patients. Clinical observations suggest an even higher risk during pregnancy. OBJECTIVES We sought to determine the incidence and causes of heparin-induced skin reactions during pregnancy in a prospective cohort study. METHODS Pregnant women with subcutaneous heparin treatment were prospectively examined for skin reactions… CONTINUE READING
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Diagnosis of heparin-induced delayed-type hypersensitivity

  • M Schindewolf, RJ Ludwig, M Wolter, K Hardt, R Kaufmann, E Lindhoff-Last
  • Phlebologie
  • 2010
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