High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11).

@article{Wieland2006HighIO,
  title={High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11).},
  author={Ilse Wieland and Petra Muschke and Marianne Volleth and Albrecht Roepke and Antje-Friederike Pelz and Markus Stumm and Peter F. Wieacker},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 10},
  pages={945-9}
}
In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation-specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing… CONTINUE READING

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