High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication.

@article{Corallini1977HighIO,
  title={High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication.},
  author={Alfredo Corallini and Giuseppe Barbanti-Brodano and W Bortoloni and Italo Nenci and Enzo Cassai and Micaela Tampieri and Marinella Portolani and Monica Borgatti},
  journal={Journal of the National Cancer Institute},
  year={1977},
  volume={59 5},
  pages={1561-4}
}
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendal virus-mediated fusion with Vero cells. A low, or lack of, oncogenic… CONTINUE READING