High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma.

@article{Ueda2002HighIO,
  title={High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma.},
  author={Eiichiro Ueda and Shogo Kurebayashi and Morito Sakaue and Michael Hawley Backlund and Beverly H. Koller and Anton M Jetten},
  journal={Cancer research},
  year={2002},
  volume={62 3},
  pages={
          901-9
        }
}
Nuclear receptors are critical regulators of many physiological processes and have been shown to be involved in a variety of disease processes, including malignant neoplasms. Our laboratory is investigating the function of the retinoid-related orphan receptor gamma (RORgamma) and its possible role in disease. Studies of mice deficient in the expression of RORgamma demonstrated that this receptor plays a crucial role in the regulation of thymopoiesis and lymph node organogenesis. In this study… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

E2A deficiency leads to 908 T-CELL LYMPHOMAS IN ROR -DEFICIENT MICE on April 13, 2017

G. Bain, I. Engel, +7 authors C. Murre
  • Mol. Cell. Biol.,
  • 2002
VIEW 1 EXCERPT

Estrogen receptor-mediated processes in normal and cancer cells.

  • Journal of the National Cancer Institute. Monographs
  • 2000
VIEW 1 EXCERPT

Mammary tumor formation in p53- and BRCA1-deficient mice.

  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1999
VIEW 1 EXCERPT