High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia.

@article{Anderson2010HighHO,
  title={High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia.},
  author={Tim Anderson and Shalini K. Nair and Standwell C Nkhoma and J. Tudno Williams and Mallika Imwong and Poravuth Yi and Duong Socheat and Debashish Das and Kesinee Chotivanich and Nicholas P J Day and Nicholas J White and Arjen M Dondorp},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={201 9},
  pages={
          1326-30
        }
}
In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion (56%-58%) of the variation in clearance rate is explained by parasite genetics… CONTINUE READING
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