High growth rate and substrate exhaustion results in rapid cell death and lysis in the thermophilic bacterium Geobacillus thermoleovorans.

@article{Pavlostathis2006HighGR,
  title={High growth rate and substrate exhaustion results in rapid cell death and lysis in the thermophilic bacterium Geobacillus thermoleovorans.},
  author={Spyros G Pavlostathis and Roger Marchant and Ibrahim M Banat and Nigel G Ternan and Geoffrey McMullan},
  journal={Biotechnology and bioengineering},
  year={2006},
  volume={95 1},
  pages={84-95}
}
Batch cultures of the thermophilic bacterium Geobacillus thermoleovorans T80 attained extremely high-specific glucose utilization rates leading to high specific growth rates, followed by extensive cell death and lysis with the onset of substrate exhaustion. The dramatic decrease in live cell numbers, as determined by flow cytometry, was accompanied by the release of soluble protein. Once the growth phase reached the point of commitment to lysis created by the impending exhaustion of substrate… CONTINUE READING

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