High-grade squamous intraepithelial lesion (CIN 2 and 3) excised with negative margins by loop electrosurgical excision procedure: the significance of CIN 1 at the margins of excision.

@article{CardozaFavarato2007HighgradeSI,
  title={High-grade squamous intraepithelial lesion (CIN 2 and 3) excised with negative margins by loop electrosurgical excision procedure: the significance of CIN 1 at the margins of excision.},
  author={Gabriella Cardoza-Favarato and Oluwole Fadare},
  journal={Human pathology},
  year={2007},
  volume={38 5},
  pages={
          781-6
        }
}
The significance of cervical intraepithelial neoplasia grades 2 or 3 (CIN 2-3) at the margin of a loop electrosurgical excision procedure (LEEP) specimen as a predictor of recurrent or persistent disease is relatively controversial. Most studies have found the presence of high-grade dysplasia at the margins in this setting to be an adverse parameter. However, the significance of an isolated finding of CIN 1 at the surgical margins of LEEP specimens has not been rigorously studied. Herein, we… CONTINUE READING
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