High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate

  title={High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate},
  author={Ming Zhou},
  journal={Modern Pathology},
  • Ming Zhou
  • Published 3 January 2018
  • Medicine
  • Modern Pathology
Many prostate lesions have 'large gland' morphology with gland size similar to or larger than benign glands, complex glandular architecture including papillary, cribriform, and solid, and significant cytological atypia in glandular epithelium with nucleomegaly, prominent nucleoli, or anisonucleosis. The most common and clinically important lesions with 'large gland' morphology include high-grade prostatic intraepithelial neoplasia (HGPIN), PIN-like carcinoma, ductal adenocarcinoma, and… 

Pathology of the Benign and Malignant Diseases of the Prostate

This chapter discusses the classification, grading, staging, and current definition of clinically significant PCa, as well as tissue biomarkers predicting upgrading and/or significant disease and tissue-based genomic tests for diagnosis and prognosis.

Isolated Intraductal Carcinoma of the Prostate in Prostatectomy Specimens: Report of 2 Cases and Review of the Literature

The existence of isolated IDCc reinforces the idea that, at least in some of the cases, IDCp is a precancerous lesion, and further molecular studies need to be performed in order to clarify its pathogenesis.

Cribriform Patterned Lesions in the Prostate Gland with Emphasis on Differential Diagnosis and Clinical Significance

The aim of this review is to summarize the current knowledge regarding the morphological features, differential diagnosis, molecular profile and clinical significance of the cribriform-patterned entities of the prostate gland.

Optimizing the diagnosis and management of ductal prostate cancer

The genomic makeup of DAC resembles castration-resistant PAC and warrants aggressive therapy, including the use of upfront use of novel systemic or combination therapies in neoadjuvant, adjuvant and metastatic settings.

Identification of Morphologic Criteria Associated with Biochemical Recurrence in Intraductal Carcinoma of the Prostate

The results suggest that IDC-P can be classified as low versus high-risk of BCR and the defined morphologic criteria can be easily assessed and should be integrated for clinical application following validation in larger cohorts.

Histologic Variants of Acinar Adenocarcinoma, Ductal Adenocarcinoma, Neuroendocrine Tumors, and Other Carcinomas

This chapter outlines important clinical and pathologic characteristics of histologic variants of acinar adenocarcinoma, ductal adenOCarcinomas, neuroendocrine tumors, and other carcinomas.

Cribriform morphology in prostate pathology

  • F. Siadat
  • Medicine
    Diagnostic Histopathology
  • 2018

Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component

It is confirmed that canine PC is characterized by absent or weak expression of basal cell and urothelial markers, and NSE expression, potentially indicating neuroendocrine differentiation, is reported for the first time in canine PCa.



Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia

Recognition of this pattern of prostatic adenocarcinoma with stratified malignant glandular epithelium can be identified in prostate needle biopsy samples harboring non-cribriform prostaticAdenocARCinoma and resembles glands with high-grade prostatic intraepithelial neoplasia.

Spread of adenocarcinoma within prostatic ducts and acini. Morphologic and clinical correlations.

It was concluded that intraductal prostatic adenocarcinoma is a common morphologic entity with precisely defined histologic criteria and a unique biologic significance, as reflected by an enhanced capacity for extensive spread within ducts and perineural spaces.

High-grade Prostatic Intraepithelial Neoplasialike Ductal Adenocarcinoma of the Prostate: A Clinicopathologic Study of 28 Cases

28 cases of ductal adenocarcinomas on needle biopsy and transurethral resection of prostate closely resembling high-grade prostatic intraepithelial neoplasia composed of simple glands with flat, tufting, or micropapillary architecture are reported.

Intraductal carcinoma of the prostate.

It is critical to recognize Intraductal carcinoma of the prostate, especially in prostate biopsies in which the clinical implications of IDC-P are greatest, and to review the historic perspectives, pathologic and genetic features, diagnostic criteria and differential diagnoses, and the clinical significance of IDc-P.

Atypical Cribriform Lesions of the Prostate: Clinical Significance, Differential Diagnosis and Current Concept of Intraductal Carcinoma of the Prostate

The morphologic and molecular characteristics of IDC-P and cribriform HGPIN are summarized and an approach to work-up of atypical cribRiform lesions in prostate needle biopsies is summarized.

A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma.

Intraductal carcinoma of the prostate as defined by major criteria that include enlarged gland structures, neoplastic cells spanning the gland lumen, central comedonecrosis, and further supported by minor diagnostic criteria including molecular biological markers, separate this entity from HG-PIN.

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization

It is confirmed that morphologically distinct HGPIN and nearby invasive cancer lesions are clonally related, and it is suggested that invasive adenocarcinoma can morphologically mimic H GPIN through retrograde colonization of benign glands with cancer cells.

Cytoplasmic PTEN Protein Loss Distinguishes Intraductal Carcinoma of the Prostate from High Grade Prostatic Intraepithelial Neoplasia

PTEN loss is identified as a potentially useful marker to distinguish intraductal carcinoma from PIN and provides a plausible molecular explanation for why intraductive carcinoma is associated with poor prognosis.

Histopathological features of ductal adenocarcinoma of the prostate in 1,051 radical prostatectomy specimens

Ductal adenocarcinoma and DACB are more aggressive than average PAC, while cancers with acinar architecture and pseudostratified high-grade nuclei should not be included in DAC.

Atypical Cribriform Lesions of the Prostate: Relationship to Prostatic Carcinoma and Implication for Diagnosis in Prostate Biopsies

The incidence, topographic relation to cancer, and morphologic differences of these 2 lesions in radical prostatectomy are reported and the potential biologic basis and implication for diagnosis in prostate biopsy are discussed.