High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.

@article{Wei2006HighgradeGF,
  title={High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.},
  author={Qingxia Wei and Laura Clarke and Danielle K. Scheidenhelm and Baoping Qian and Amanda Tong and Nesrin Sabha and Zia Karim and Nicholas A. Bock and Robert Reti and Rolf Swoboda and Enkhtsetseg Purev and Jean-François Lavoie and Michaela Livia Bajenaru and Patrick Shannon and Dorothee M Herlyn and David Kaplan and R. Mark Henkelman and David H Gutmann and Abhijit Guha},
  journal={Cancer research},
  year={2006},
  volume={66 15},
  pages={7429-37}
}
High-grade gliomas are devastating brain tumors associated with a mean survival of <50 weeks. Two of the most common genetic changes observed in these tumors are overexpression/mutation of the epidermal growth factor receptor (EGFR) vIII and loss of PTEN/MMAC1 expression. To determine whether somatically acquired EGFRvIII expression or Pten loss accelerates high-grade glioma development, we used a previously characterized RasB8 glioma-prone mouse strain, in which these specific genetic changes… CONTINUE READING
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