High-grade acute organ toxicity and p16INK4A expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma

@article{Tehrany2014HighgradeAO,
  title={High-grade acute organ toxicity and p16INK4A expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma},
  author={Narges Tehrany and Julia Kitz and Margret Rave-Fr{\"a}nk and Stephan S. Lorenzen and Lin Li and Stefan K{\"u}ffer and PhD Clemens F. Hess and Peter Burfeind and Holger M. Reichardt and Martin Canis and Tim Beissbarth and PD Dr. med. Hendrik Andreas Wolff},
  journal={Strahlentherapie und Onkologie},
  year={2014},
  volume={191},
  pages={566-572}
}
Superior treatment response and survival for patients with human papilloma virus (HPV)-positive head and neck cancer (HNSCC) are documented in clinical studies. However, the relevance of high-grade acute organ toxicity (HGAOT), which has also been correlated with improved prognosis, has attracted scant attention in HPV-positive HNSCC patients. Hence we tested the hypothesis that both parameters, HPV and HGAOT, are positive prognostic factors in patients with HNSCC treated with definite… CONTINUE READING

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