High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.

Abstract

Loss of chromosome 10 was observed in 10 out of 12 xenografted glioblastomas studied. Chromosome 10 carries the gene coding the hexokinase type 1 isoenzyme (HK-I), which catalyses the first step of glycolysis, which is essential in brain tissue and glioblastomas. We investigated the relationships between the relative chromosome 10 number, the amount of HK-I… (More)
DOI: 10.1038/bjc.1996.446

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