High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice.

@article{Hao2012HighglycemicIC,
  title={High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice.},
  author={Qin Hao and Haldis Hauk{\aa}s Lillefosse and Even Fjaere and Lene Secher Myrmel and Lisa Kolden Midtb{\o} and Ragnhild Helene Jarlsby and Tao Ma and Bingbing Jia and Rasmus K. Petersen and Si B. Sonne and Andr{\'e} Chwalibog and Livar Fr{\o}yland and Bj{\o}rn Liaset and Karsten Kristiansen and Lise Madsen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={302 9},
  pages={
          E1097-112
        }
}
Fish oil rich in n-3 polyunsaturated fatty acids is known to attenuate diet-induced obesity and adipose tissue inflammation in rodents. Here we aimed to investigate whether different carbohydrate sources modulated the antiobesity effects of fish oil. By feeding C57BL/6J mice isocaloric high-fat diets enriched with fish oil for 6 wk, we show that increasing amounts of sucrose in the diets dose-dependently increased energy efficiency and white adipose tissue (WAT) mass. Mice receiving fructose… 
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Of mice and men: Factors abrogating the antiobesity effect of omega-3 fatty acids.
TLDR
The recent finding that sucrose and other high glycemic index carbohydrates abrogate the antiobesity effect of n-3 PUFAs might, at least in part, provide an explanation to the apparent discrepancy between human and rodent intervention studies, and the lack of effect in some human trials.
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TLDR
It is found that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, high fat challenge significantly increased body weight, suggesting that lipogenesis in mammals is synergistically influenced by DHA dietary and sucrose content.
The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during Ad Libitum Feeding and Energy Restriction in Already Obese Mice
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In obese mice, ad libitum intake of a low-fat diet stabilized body weight, reduced fat mass and increased lean body mass, with the highest loss of fat mass found in mice fed the casein-based diet.
Anti-obesity effect of n-3 polyunsaturated fatty acids in mice fed high-fat diet is independent of cold-induced thermogenesis.
TLDR
The results demonstrated anti-obesity metabolic effect of LC n-3 PUFA, independent of cold-induced thermogenesis and they suggested that induction of fatty acid re-esterification creating a substrate cycle in white fat, which results in energy expenditure, could contribute to the anti-Obesity effect.
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TLDR
It is demonstrated that intake of high protein diets based on other protein sources may not have similar effects, and hence, the obesity protective effect of highprotein diets is clearly modulated by protein source.
Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids
TLDR
Compared with triglycerides, dietary DHA/EPA administered as phospholipids are superior in preserving a healthy metabolic profile under obesogenic conditions, possibly reflecting better bioavalability and improved modulation of the endocannabinoid system activity in WAT.
Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain.
Of mice and men
TLDR
The recent finding that sucrose and other high glycemic index carbohydrates abrogate the antiobesity effect of n-3 PUFAs might, at least in part, provide an explanation to the apparent discrepancy between human and rodent intervention studies, and the lack of effect in some human trials.
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