High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy.

@article{Wolf1997HighGS,
  title={High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy.},
  author={Gunter B Wolf and Regine Schroeder and Fuad N. Ziyadeh and Friedrich Thaiss and Gunther Zahner and Rolf A K Stahl},
  journal={The American journal of physiology},
  year={1997},
  volume={273 3 Pt 2},
  pages={F348-56}
}
Hypertrophy of mesangial cells is an early hallmark of diabetic nephropathy. We have previously shown that murine mesangial cells (MMC), cultured in high-glucose medium, are arrested in the G1 phase of the cell cycle and undergo hypertrophy. This study was undertaken to test whether high glucose-containing medium influences the expression of p27Kip1, an inhibitor of G1 phase active cyclin-dependent kinases (CDK). Incubation of MMC, in the absence of other factors for 48-96 h, in medium… CONTINUE READING

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