High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326/CXCL13 pathway.

@article{Cao2016HighGP,
  title={High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326/CXCL13 pathway.},
  author={Boran Cao and Ning Liu and Wenbo Wang},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={84},
  pages={544-551}
}
BACKGROUND High glucose (HG) often induces unfavorable effects on proliferation and differentiation of mesenchymal stem cells (MSCs). This study aimed to explore potential molecular pathways underlying HG functional mechanism during osteogenic differentiation of MSCs, involving lncRNA AK028326 and CXCL13. METHODS Murine bone marrow-derived MSCs were cultured in osteogenic-inducing medium supplemented with high glucose level at 25mM or 5.5mM as normal control. Expression levels of lncRNA… CONTINUE READING