High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes.

@article{Thilo2014HighGM,
  title={High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes.},
  author={Florian Thilo and Marlene Lee and Shengqiang Xia and Andreas Zakrzewicz and Martin Tepel},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={450 1},
  pages={312-7}
}
Transient receptor potential canonical (TRPC) channels type 6 play an important role in the function of human podocytes. Diabetic nephropathy is characterized by altered TRPC6 expression and functions of podocytes. Thus, we hypothesized that high glucose modifies TRPC6 channels via increased oxidative stress and syndecan-4 (SDC-4) in human podocytes. Human… CONTINUE READING