High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.

@article{Park2001HighGI,
  title={High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.},
  author={Sung Hee Park and Hyung Jun Choi and Jang Hern Lee and Chang Hoon Woo and Jae Hong Kim and Ho Jae Han},
  journal={Kidney international},
  year={2001},
  volume={59 5},
  pages={1695-705}
}
BACKGROUND The alteration of renal cell growth is one of the early abnormalities in the diabetic nephropathy. However, the effects of high glucose and its action mechanism in renal proximal tubule cell (PTC) proliferation have not been elucidated. METHODS The effects of 25 mmol/L glucose on cell proliferation, thymidine, and leucine incorporation, cell cycle, and lipid peroxide formation were examined in the primary cultured renal PTCs. RESULTS Glucose 25 mmol/L inhibited [3H]-thymidine… CONTINUE READING
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