High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

@article{Zhang2012HighGI,
  title={High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.},
  author={Lanyu Zhang and Shanshan Pang and Bo Deng and Lihua Qian and Juan Chen and Junjie Zou and Jiaoyang Zheng and Linghui Yang and Chunyang Zhang and Xiangfang Chen and Zhimin Liu and Yingying Le},
  journal={The international journal of biochemistry & cell biology},
  year={2012},
  volume={44 4},
  pages={629-38}
}
Renal hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy. Hyperglycemia-induced oxidative stress is implicated in the etiology of diabetic nephropathy. Resveratrol has potent antioxidative and protective effects on diabetic nephropathy. We aimed to examine whether high glucose (HG)-induced NADPH oxidase activation… CONTINUE READING